Effects of 7-BIA on Established Cocaine Self-Administration.

WT or heterozygous PTPRD-KO mice were prepared by external jugular vein catheterization and allowed to self-administer 0.5–1 mg/kg per infusion of cocaine for at least 20 prior sessions on FR1 and/or progressive ratio schedules. Mice that were self-administering at least 40 (of 50 possible) times per 3-h session on FR1 schedules were studied. Ninety minutes before the start of the subsequent self-administration session, mice were pretreated with vehicle or 10 or 20 mg/kg 7-BIA (i.p.) and allowed to self-administer 1 mg/kg per infusion of cocaine for a 3-h session. During the next sessions, mice were allowed to self-administer 1 mg/kg per infusion of cocaine without pretreatment. The numbers of cocaine infusions self-administered were noted.