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The inhibition of membrane transporters OCT‐2, OCT‐3, OAT‐3, MATE1, and MATE2‐K or bile acid transporters ASBT, MRP1, MRP2, MRP3, NTCP, and BSEP was evaluated in vitro at drug concentrations up to 240 μg/mL by measuring the inhibition of transporter‐specific substrate transport across cell membranes in cell lines stably expressing the respective transporter as previously described.31, 32, 33, 34
Copyright and License information: ©2016 The Authors. Published by Wiley Periodicals, Inc. on behalf of The American College of Clinical Pharmacology
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