Acquisition of drug screening data

The therapeutic anticancer drug screening data for NCI-60 human tumor cell lines were obtained from the NCI/NIH Developmental Therapeutics Program (DTP) (www.dtp.nci.nih.gov). This dataset, released in July 2012, provides the GI₅₀ values characterizing the sensitivity of NCI-60 DTP human tumor cell lines to 50,839 compounds⁴. The GI₅₀ value is defined as the concentration of a compound required to inhibit cell growth by 50% at 48 hours after compound treatment compared with DMSO vehicle treatment. The DrugBank database has widely been used to facilitate drug discovery and in silico drug target discovery³⁵.