Pancolonic modified Mayo score

Pancolonic Modified Mayo Score (panMayo) was calculated with the combination of disease extension and severity (Table ​(Table1).1). The eMayo Score of the five colorectal segments (ascendending, transverse, descendending, sigmoid colon and rectum) was determined separately and added afterwards. Finally, the sum was multiplied by the Inflammatory Constant if eMayo was ≥2 at least in one segment to clearly distinguish between the active and inactive disease. Inflammatory constant (IC = 3) was defined at the beginning of the study as the smallest number that can equilibrate the difference between the sum of the inactive and active cases resulting a broad range from 0 [normal] to 45 [most severe, pancolitis with eMayo 3 in each segment]). Inclusion of IC is important, because calculation without IC results the same points in some cases, thus it would be impossible to distinguish different extent and activity by panMayo Score. The most important unmet need for widely used scoring systems in clinical practice that the score simultaneously reflect on the severity and the extension of the disease. The aim of panMayo score was to compensate this gap. If you heard that the eMayo score is 3 points, you do not know that what is the extension of disease and what is therefore exactly the clinical severity of the disease. In contrary, panMayo Score includes both parameters, for example panMayo 45 points is a pancolitis with severe inflammation in all segments.

Calculation of panMayo score

Explanation:

Involvement: rectum: 1 point, rectum-sigmoid: 2 points, descending colon: 3 points, transverse colon: 4 points, cecum/ascending colon: 5 points

If no Inflammation (eMayo 0–1 points): eMayo points x involvement [1–5]

If active inflammation is presented in any segment: eMayo points x involvement [1–5] × 3

We analysed the correlation of panMayo Score with the endoscopic indices and the complicated disease outcome. The panMayo Score was compared with Endoscopic Mayo Score and UCEIS to assess the utility of our new score. Complicated disease outcome was defined as the need of hospitalization and/or colectomy during the follow-up.