3.8. Synthesis of N-1,3-Benzothiazol-2-yl-2-chloroacetamide (15)

A mixture of 2-amino-1,3-benzothiazole (0.100 g), sodium bicarbonate (3 equiv) in acetone (10 mL), was stirred at 5 °C. After 30 min, chloroacetyl chloride (1.5 equiv.) was added dropwise using a drop funnel apparatus and stirred at room temperature for 8 h. Once the reaction was completed, the solvent was removed in vacuo, and the white precipitated was washed with cold water. Yield: 90%, m.p.: 156.5–159.3 °C; ¹H-NMR (CDCl₃) δ: 4.32 (s, CH₂), 7.36 (t, H-6, J = 8.10 Hz), 7.48 (t, H-5, J = 8.28 Hz), 7.84 (q, H-4, H-7, J = 7.92 Hz); MS-EI: m/z 225.75 (M⁺) 40%, 149.61(M − 77) 100%.