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General linear mixed models were utilized to assess the differences in all study variables measured with saline (baseline) and vitamin C. The predictors were intervention, disease status, and the interaction between intervention and disease status; the model was also adjusted for sex. Starting from the model with the two-way interaction terms, we examined and removed the two-way interactions at an alpha = 0.05 level. All of the main effects were included in the final model. Residual diagnostics were used to assess the assumptions of our modeling approach.
Copyright and License information: The Author(s) ©2018
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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