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HH Hao Hu
HL Haiyan Li
JL Jieqiong Li
JY Jintai Yu
LT Lan Tan
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Our ADNI cohort included all healthy controls (HC), MCI group and AD group participants with available baseline CSF BACE samples and genotype data. To reduce the likelihood of population stratification effects in the GWAS, all the participants were restricted to non-Hispanic Caucasians. We also tested a multidimensional scaling (MDS) plot and found some genetic outliers (Additional file 1). After quality control (QC) of the CSF BACE data and removal of the outliers, there were 340 participants (AD = 86, MCI = 163, HC = 91) with CSF BACE data left. Detailed QC steps for CSF and genotype data have been previously reported and are briefly described below.

Copyright and License information: The Author(s). ©2018
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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