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Drug sensitivity screening was performed using whole BM cells of Asxl1Y588XTg and wild-type (WT) mice with an array of 165 epigenetic compounds, covering inhibitors for HDAC, DNA methyltransferase, BET bromodomain, and some other targets. Positive hits were further evaluated for their dose response. Dose response curves were generated for each compound. Modified drug sensitivity score (DSSmod) was calculated as described previously.23
Copyright and License information: ©2018 by The American Society of Hematology
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