Datasets

The summary statistics of height, BMI and WHRadjBMI were downloaded from the GIANT consortium website (https://www.broadinstitute.org/collaboration/giant/index.php/GIANT_consortium_data_files). The downloaded data include sex-specific [17] and sex-combined [6–8] GWASs meta-analysis summary statistics from the discovery phase. For discovery stage in sex- specific studies, 46 studies (up to 60,586 males, 73,137 females) on height and BMI and 32 studies (up to 34,629 males, 42,969 females) on WHR were included [17]. In the discovery phase of sex-combined studies, summary statistics were collected from 46 GWASs in a meta-analysis of 133,653 individuals (60,587 males and 73,066 females) for height [6], 46 studies with up to 123,865 individuals for BMI [7], and 32 studies with up to 77,167 individuals (34,601 males and 42,735 females) for WHRadjBMI [8].