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We conducted a systematic review of N-of-1 clinical trials published in journals indexed by PubMed, CINAHL, Web of Science and the Cochrane Central Register of Controlled Trials as well as publications from grey literature and unpublished sources from International Trial Registry Platforms between 1985 and 2015. The protocol for this review was developed based on the PRISMA Statement [29] and is registered at PROSPERO (PROSPERO CRD42015026841). The PRISMA Checklist can be found in Additional file 1. The review did not require Human Subjects Approval.
Copyright and License information: The Author(s). ©2018
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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