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Compound 13: N-(4-(3-Fluoro-4-methylphenyl)thiazol-2-yl)-5-nitrothiophene-2-carboxamide
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Compound 13 was synthesized using scheme and procedure analogous to compound 7 from commercially available 2-Amino-4-(4′-fluoro-3′-methyl) phenylthiazole (CAS: 3830-48-6, Combi- Block) and 5-Nitro-2-thiophencarboxylic acid.
1H NMR (400 MHz, DMSO-d6) δ = 13.35 (bs, 1H), 8.23-8.28 (m, 2H), 7.83 (s, 1H), 7.68-7.71 (m, 2H), 7.35-7.39 (m, 1H), 2.27 (s, 3H). LCMS: Calculated for C15H10FN3O3S2 = 363.38, Observed = 364.0. HPLC = 94.24% (HPLC Column: Phenomenex Gemini-NX C18 (150 × 4.6 mm) 5 micron, Mobile Phase A: 10 mM Ammonium acetate in water, Mobile Phase B:
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