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Streptozotocin (STZ) - Induced Diabetes
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The rats were given a single intraperitoneal dose of STZ 50 mg/kg body weight (Alfa Aesar, A Johnson Matthey Company, MA/USA, CAS: 18883-66-4) to produce DM [15]. Random blood sugar (RBS) was measured from a blood drop drawn from the tail vein using glucometer (Accu - Chek Go, Roche Diagnostic, Germany) after 4 days of STZ injection. The rats with RBS >300 mg/dl were enrolled in the study. Insulin neutral protamine Hagedorn (5 IU/kg body weight; Wosulin, Wockhardt Limited, India) was given subcutaneously, once a day to maintain the RBS between 250 and 350 mg/dl.
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