CN injection

CN Suspension Injection (trade name: Kanalin) was designed by Chongqing LUMMY Pharmaceutical Co., Ltd. Specific processes (like organic solvent dissolution; magnetically stir, distillation and ultrasonic processing) changed aggregation of nanoscale carbon particles and formed polymer with 150 nm diameter. The gap between capillary lymphatic endothelial cells is 100–500 nm while that between the capillary endothelial cells is only 30–50 nm. Therefore, after being injected into the thyroid tissue, they will rapidly enter the lymphatic vessels, rather than vascular vessels, and then enter the lymphatic capillaries after having been engulfed by macrophages. Finally, they accumulated in the lymph nodes, resulting in the black-staining of the lymph nodes (Fig. 1). The CN suspension injection is mainly used for tracing the regional lymph node lesions. Usually after the exposure of the operative field, it can be injected at the amount of 25 mg with a 1 ml needle slowly and injected at the four to six points in the tumor periphery area. Each point of injection ranges from 5–15 mg and it takes about 3 minutes. Rare adverse effects are reported. Occasional fever occurred, which patients often could tolerate.

The number of central lymph node dissection. (R, VI), the dissected lymph nodes on the right thyroid lobe of the right central area in CN group; (L, VI), the dissected lymph nodes on the left side of the central area for the same patient without CN injection.