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Swertia punicea was collected from Dali, Yunnan Province, China, and identified by Guang-Xue Liu (Department of Natural Drugs, School of Pharmaceutical Science, Peking University). A voucher specimen (SP-001) was deposited in the herbarium of the Department of Pharmacognosy, School of Pharmaceutical Sciences, Peking University, Beijing. ZYC-1 was extracted and separated from Swertia punicea as zheng’s reported method [9]. The purity of the compound ZYC-1 was determined to be more than 98% by high-performance liquid chromatography (HPLC) analysis and the chemical structure of the compound ZYC-1 was shown in the supporting information (S1 Fig).

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