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Locomotor activity was measured individually for each mouse using OPTO-M3 locomotor activity cages (Columbus Instruments, Columbus, OH, USA) attached to a compatible personal computer. Each cage (13 × 23 × 15 cm) was connected to an array of photocell beams. Each photobeam interruption was recorded as horizontal activity, which comprised the ambulation scores. The experimental design for locomotor activity measurements was the same as described for the ASST; however, different animals completed the locomotor activity test and the ASST.
Copyright and License information: The Author(s) ©2017
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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