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In vitro release of 5-FU was observed at 37°C in simulated gastric fluid (SGF, pH 1.2) and simulated intestinal fluid (SIF, pH 7.4). At specific time intervals, 3 ml of sample solution containing released drug was taken. The absorbance of released drug was determined by UV-vis spectrometer at 266 nm. Drug release experiments were observed in triplicate, average of drug release was calculated as in Eq 10.
Copyright and License information: ©2017 Bashir et al
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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