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Conditional association analysis

YZ Yong-Biao Zhang
JH Jintian Hu
JZ Jiao Zhang
XZ Xu Zhou
XL Xin Li
CG Chaohao Gu
TL Tun Liu
YX Yangchun Xie
JL Jiqiang Liu
MG Mingliang Gu
PW Panpan Wang
TW Tingting Wu
JQ Jin Qian
YW Yue Wang
XD Xiaoqun Dong
JY Jun Yu
QZ Qingguo Zhang
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To identify other independently associated SNPs at a significant locus, we performed a conditional analysis on genotyped and imputed data using Plink. We first conducted association tests on the remaining significant SNPs by adjusting for the most significantly one at that locus. We then repeated the test with adjustment of the most significant one plus the remaining variants until no further genome-wide significant SNPs could be remained. Independently associated SNPs were those who have P value <0.05 after Bonferroni's adjustment in conditional association test.

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