The study design is presented in Figure Figure1.1. The 16 monkeys were randomly divided into four groups after an ICP sensor was implanted and then were given different doses of D-gal according to the results of our previous study[19]. The study groups and dosages given were as follows: group A (n = 4), 0.30 g/kg D-gal; group B (n = 4), 0.25 g/kg D-gal; group C (n = 4), 0.20 g/kg D-gal plus 0.05 g/kg D-gal after 24 h; group D (n = 4), 0.20 g/kg D-gal.
Study design. All monkeys were randomly divided into four groups after ICP sensor implantation; the interval of D-gal administration to group C was 24 h. ICP: Intracranial pressure.
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