This prospective observational study was conducted across six European hospitals over an 18-month period (February 2014–August 2015). The six centres involved were Cork University Hospital (Cork, Ireland), Universitair Ziekenhuis Gent (Ghent, Belgium), Hospital Universitario Ramón y Cajal (Madrid, Spain), Azienda Ospedali Riuniti (Ancona, Italy), Landspitali University Hospital Reykjavik (Reykjavik, Iceland) and Aberdeen Royal Infirmary (Aberdeen, Scotland).
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