Structural sequence alignments were done with Swiss PDB Viewer [45] and Espript [46]. For structure analyses, PyMOL and UCSF Chimera [47] were used. Superpositions were done with the SSM algorithm [48], and structural homologues were searched using Salami [49]. Modeling of the substrate complex and a complex with a 3-base RNA oligonucleotide was done in YASARA [50]. Electrostatic surfaces were calculated using PDB2PQR and ABPS [51].
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