Study selection

The primary criteria weighed in including a literature were studying the oncologic outcomes of RCC, using pretreatment PLR or LMR as prognostic indicators and investigating their association with survival outcomes including OS, RFS and PFS. Articles were excluded if they (a) were presented in non-English; (b) were short of adequate data for calculating HRs and their 95% CIs; (c) reported PLR or LMR as continuous variables; (d) studied post-treatment PLR or LMR. When one center published more than one article about the same study population, we just included the most comprehensive and latest study. Two reviewers independently considered all the articles that met the inclusion criteria for full-text review. Any disagreements were discussed and arbitrated by a third reviewer.