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One-day-old WT mice were injected intraperitoneally (i.p.) with 1 (L 1), 5 (L 5) or 15 (L 15) mg/kg of leflunomide or the vehicle, PEG (control), once daily for 4 d. Similarly, one-day-old AhR-null mice were injected intraperitoneally with either the vehicle, PEG, or with 15 mg/kg (L 15) of leflunomide once daily for 4 d. Following the injections, the lung and liver tissues were harvested to determine the expression of CYP 1A1/A2 and NQO1 enzymes.
Copyright and License information: ©2017
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