Effects of co-administration of F. asperifolia and bicalutamide

To verify the use of cytoplasmic or nuclear androgen receptors by F. asperifolia, twenty five castrated rats were divided into 5 groups of 5 animals each and treated with one of the following: bicalutamide (2 mg/kg b.w.) plus testosterone (0.5 mg/kg b.w.); bicalutamide (2 mg/kg b.w.) plus aqueous extract of F. asperifolia (100 mg/kg b.w. or 500 mg/kg b.w.); bicalutamide (2 mg/kg b.w.) plus methanolic extract of F. asperifolia (100 mg/kg b.w. or 500 mg/kg b.w.).

All test substances were administered once a day for 4 weeks. Testosterone was given subcutaneously while F. asperifolia, bicalutamide and the solvents were given orally at the volume 10 ml/kg b.w.