Ethics statement

All animals were handled in a facility certified by the French Ministry of Agriculture (approval ID B-31-555-10) and in accordance with the guidelines from the European directive on the protection of animals used for scientific purposes (2010/63/UE), French Decret 2013–118. MR and PB have received an authorisation to experiment on vertebrates models (N° 311255556 and N° 311255553) from the ‘Direction Départementale de la Protection des Populations de la Haute-Garonne’. All anaesthesia and euthanasia procedures were performed in Tricaine Methanesulfonate (MS222) solutions as recommended for zebrafish (0,16mg/ml for anaesthesia, 0,30 mg/ml for euthanasia). All efforts were made to minimize the number of animals used and their suffering, according to the guiding principles from the Decret 2013–118.