To test whether fecal elastase measurements in routine clinical use are affected by enzyme replacement therapy we selected eight patients with moderate to severe exocrine pancreatitis insufficiency and compared their stool elastase measurements before, and after a minimum of 4 months following the initiation of conitiuous pancreatic enzyme replacement therapy with a minimum of 200.000 units of lipase per day using the polyclonal fecal elastase assay (BIOSERV Diagnostics GmbH, Greifswald).
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