Forced degradation studies

Forced degradation studies of CUR, DMC, BDMC, and curcuminoid mixture were carried out as per ICH recommended stress conditions such as acidic, basic, oxidative, thermal, and photolytic conditions [18]. For each degradation study, four samples were prepared as follows: first was the blank solution stored under normal conditions, second was the blank subjected to degradation in the similar manner as the drug solution, third was the zero time sample containing the drug stored under normal conditions and fourth was the drug solution subjected to degradation.