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The image registration quality was measured by calculating the average mean-squared-signal-difference (MSSD) metric between the three-dimensional reference image and each of the 3D temporal phases of the fat images in the original, fat- and water-based registration methods. The statistical differences between the original and the new registration methods were measured using a repeated measures ANOVA test with p<0.05. Pairwise statistical differences between original, water- and fat-based registration methods was determined using Tukey – Kramer method with p<0.05.
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