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Pilocarpine Model of Epilepsy
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Rats were submitted to the pilocarpine model of epilepsy. A single pilocarpine injection (320 mg/kg, i.p.) was given to the rats. To block the peripheral effects of pilocarpine, rats were pretreated with methyl scopolamine (1 mg/kg, i.p.). Animals developed status epilepticus (SE) for 90 min and thereafter were treated with Tionembutal® (Cristalia, 25 mg/kg, i.p.) to stop the SE and reduce the mortality rate.
Copyright and License information: ©2016 John Wiley & Sons Ltd
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