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Pharmacokinetic Sampling and Analysis

LM Lisa C. Martial
RH Rob ter Heine
JS Jeroen A. Schouten
NH Nicole G. Hunfeld
HL Henk J. van Leeuwen
PV Paul E. Verweij
DL Dylan W. de Lange
PP Peter Pickkers
RB Roger J. Brüggemann
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At day 3 (±1) patients were intensively sampled (2 mL) at t = 0 (pre-dose) and 0.5, 1, 2, 4, 6, 8, 12, 18 and 24 h post start infusion during a dosing interval. At day 7 (±1), a second PK curve of six samples was drawn at t = 0, (pre-dose) and 1, 4, 8, 12 and 24 h post start infusion. Additional daily trough concentrations were drawn daily until 3 days after cessation of micafungin therapy. A validated ultra-performance liquid chromatography-fluorescence assay was used to analyse the samples, details have been described previously [7].

Copyright and License information: The Author(s) ©2017
Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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