We used the CAT12 toolbox (version rs1720) for pre-processing and analysis of cortical complexity data, applying the recommended default options (Computational Anatomy Toolbox 12, C. Gaser, Structural Brain Mapping Group, University of Jena, Germany).
The cortical complexity measure implemented in CAT12 is based on spherical harmonics modelling of the cortical surface using a fractal dimensions approach [46]. Surface reconstruction includes topology correction and spherical registration [46]. Cortical complexity images were smoothed with a Gaussian kernel of 20 mm FWHM (full width at half maximum).
Previous studies have used the cortical complexity measure to identify cortical folding abnormalities in neuropsychiatric disorders such as schizophrenia [46, 47] and bipolar disorder [48].
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