Statistical analyses were performed using Prism v9.3.1 (GraphPad) and data are presented as mean ± standard deviation. Significant differences were identified using Student’s t test with a significance level of 5%. To determine the extent of tumour reoxygenation in xenograft studies, log2Fc (fold change) was calculated and log2Fc > 1 was defined as reoxygenated. To compare multiple group testing for phospho-ATM staining, a two-way ANOVA using Šídák multiple comparison was performed. ‘*’ p < 0.05, ‘**’ p < 0.001, ‘***’ p < 0.0001, ‘ns’ non-significant.
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