Literature search strategy

ZH Zheng Hao
XL Xin Li
JD Jin Dai
BZ Baocheng Zhao
QJ Qing Jiang
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To identify all relevant reports on rs3740199 polymorphism and knee OA risk, we performed a systematic search for all English language papers from PubMed (the last search update was April 14, 2017), using the key words “rs3740199” or “ADAM12,” “polymorphism” or “polymorphisms” or “SNP,” “osteoarthritis” or “OA”. Additional eligible studies were identified by a manual search of the references of retrieved studies and review articles.

According to the following criteria, six studies were included in this meta-analysis: (1) was a cohort or case-control study; (2) was a study of the ADAM12 rs3740199 polymorphism and knee OA risk; and (3) contained available genotype or allele frequency of rs3740199.

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