For dichotomous outcomes, we report results using risk ratios (RRs); for continuous outcomes, we used mean differences (MDs). We calculated the 95% confidence intervals (CI) for all reported outcomes. Where possible (availability and homogeneity of data), we planned to pool treatment effects of individual trials into metanalyses using a random effects model and the Review Manager 5.3 software (The Nordic Cochrane Centre/The Cochrane Collaboration, Copenhagen, Denmark).20 This was not possible.
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