MRI Acquisition

All participants underwent neuroimaging to identify neurobiological moderators of treatment outcome. MRI scans were performed on 3T MRI systems at all EMBARC sites (CU: General Electric, Chicago, IL; MG: Siemens, Malvern, PA; TX and UM: Phillips, Andover, MA). We used rsfMRI to investigate regional interaction. Additionally, a high-resolution T1-weighted image was acquired as an anatomical reference during the same session. The rsfMRI parameters across the 4 sites were similar: single-shot echo-planar imaging, repetition time = 2000 ms, echo time = 28 ms, voxel size = 3.2× 3.2 × 3.1 mm³, 39 axial slices, 180 image volumes, and duration of 6 minutes. The high-resolution T1-weighted image parameters were also similar: 160 sagittal slices, voxel size = 1 × 1 × 1 mm³, and field of view = 256 × 256 × 160 mm³. The acquisition parameter details for each site are provided in Table S1.