Adult male Sprague‐Dawley rats (Charles River, Chatillon‐sur‐Chalaronne, France) initially weighing ~300 g were used as subjects. Animals were housed in pairs in clear filtered plastic cages deposited in ventilated racks. They were kept under controlled environmental conditions: temperature 23°C, 60% relative humidity, and reversed 12:12 hour light‐dark cycle. Food (A04 Scientific Animal Food & Engineering, Panlab) and tap water were available ad libitum. Enrichment material was placed inside the cages. The study was approved by the Animal Research Ethics Committee of Autonomous University of Barcelona and the Animal Experimentation Committee of Generalitat de Catalunya.
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