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The QALYs gained for patients in each health state are calculated based on utility estimates associated with being seizure-free, having a 50–99% reduction in seizure frequency or not responding to therapy (i.e., continuing to have uncontrolled seizures). The utility weights used in the model are based on responses from paediatric neurology experts and the literature (Frew et al., 2007). Details are reported elsewhere (NICE, 2021).
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