Study design

The study will employ a pooled analysis of RCTs based on both the study level data and level of individual participant data (IPD) whatever data are available, which are considered the optimal approach to minimize confounding factors and bias. Specifically, this analysis will focus on RCTs that have investigated the effects of nurse-led digital health programs on home blood pressure monitoring in patients with a history of stroke. The pooling of data in this context will not only be at the individual participant data (IPD) level but also at the aggregate data level. This means that summary statistics from each study, along with the raw patient data, will be combined to enhance statistical power and improve the precision of the estimated effects of the intervention. This approach will allow us to integrate findings from multiple studies, providing a more robust and generalizable understanding of the nurse-led interventions’ impact on blood pressure control among stroke survivors. Each selected RCT will be carefully assessed for compatibility in terms of intervention components, patient populations, and outcomes measured to ensure validity in the synthesis of the data.