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Quality control/quality assurance

AE Andrea Estévez-Danta
RR Rosario Rodil
JQ José Benito Quintana
RM Rosa Montes
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Quality control (QC) samples were prepared spiking a control pooled urine sample with 100 ng mL−1 of analytes (20 ng mL−1 of ISs) and processed following the optimized methodology. Two QC samples per batch (each 20 urine samples) were injected to test for method stability (tolerance set to 60–140% range, see “Method performance”). Similarly, different blanks were analyzed within batches to ensure the lack of (cross)contamination. These included system blanks (chromatographic runs without injection), process blanks (ultrapure water spiked with the IS), and storage blanks (sample tubes containing synthetic urine, prepared as described by Laube et al. [39], and stored for up to 4 weeks).

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