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Setting and instrumentation

MF Marika Falla
MV Michiel J. van Veelen
MF Markus Falk
EW Elisabeth M. Weiss
GR Giulia Roveri
MM Michela Masè
BW Bernhard Weber
AR Anna Randi
HB Hermann Brugger
KH Katharina Hüfner
GS Giacomo Strapazzon
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All trials were performed in the environmental chamber terraXcube, Eurac Research, Bolzano, Italy in October 2021 (Fig. 1). Experiments were conducted at a simulated altitude scenario equivalent to 4000 m, with volunteers exposed to hypobaric hypoxia at a constant rate of ascent of 4 m/s. terraXcube temperature, humidity, and carbon dioxide were continuously monitored and kept constant at normal indoor values.

Oxygen and air supplementation were delivered through OxyMask, designed to concentrate and redirect the flow of oxygen/air, preventing carbon dioxide re-breathing.

Belts for the monitoring system (Equivital EQ02, Hidalgo, UK) and sensors for oxygen saturation were fitted and participants received a technical introduction and safety briefing for terraXcube.

Cognitive tests were performed on dedicated laptops, which were placed on a separate desk for each participant. Participants were continuously monitored and guided (via radio commands) from the control room of terraXcube by research staff.

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