Drugs and reagents

YYHWM Chinese medicine-free decoction granules were purchased from Jiangyin Tianjiang Pharmaceutical Co. (Tianjin, China). The following ingredients were purchased: Rehmannia glutinosa (30 g; Production Batch No. 19090481), branch-fried Atractylodis macrocephalae (10 g; Production Batch No. 19120251), poria (10 g; Production Batch No. 20030691), cuttlebone (15 g; Production Batch No. 19110941), vinegar Curcuma longa (9 g; production batch No. 19120951), stir-fried Ji Nei Jin (9 g; Production Batch No. 20040621), Cymbopogon flexuosus (12 g; Production Batch No. 19081041), stir-fried danshiru (6 g; Production Batch No. 19091087), yuanzhi (6 g; Production Batch No. 19121371), Radix et Rhizoma Gastrodiae (6 g; Production Batch No. 19092681), and Radix et Rhizoma Glycyrrhizae (6 g; Production Batch No. 19111701). N-methyl-N′-nitro-N-nitrosoguanidine (MNNG; Shanghai Roan Reagent, Batch No. RH222415), ranitidine hydrochloride (Yunpeng Pharmaceutical Group Co. Ltd., Batch No. E210303), and viomycin capsules (Dezhou Bocheng Pharmaceutical Co. Ltd., Lot No. w20210401) were used in this study. PG-I, PG-II, G-17, IL-1β, IL-6, TNF-α, and IL-10 ELISA kits were purchased from Shanghai Youxuan Biotechnology Co. (E20958, YX-E21185, and YX-E21174, respectively). Antibodies against glyceraldehyde 3-phosphate dehydrogenase (GAPDH), IL-10, JAK1, and STAT3 were purchased from CST (Batch No. 5174T, 12163S, 3344T, and 9139T, respectively).