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The following drugs were used: ketamine chlorinated (10 mg/kg, i.p.; Syntec, Brazil; racemic mixture), imipramine hydrochloride (15 mg/kg, 1.p.; Sigma-Aldrich, Germany), fluoxetine hydrochloride (15 mg/kg, i.p.; EMS, Brazil), and AS605240 (15, 30, 60 mg/Kg, v.o.; Cayman, USA). All drugs were dissolved in sterile saline except AS605240, dissolved in carboxymethylcellulose. Drugs were prepared freshly under sterile conditions and administered intraperitoneally at 10 mL/kg.
Copyright and License information: ©2024 Published by Elsevier Inc. on behalf of International Brain Research Organization.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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