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In Vitro Assay of CYP11B2 and CYP11B1 Inhibition
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The in vitro effect of RO6836191 on CYP11B2 and CYP11B1 proteins was assessed in human renal leiomyoblastoma cells (ATCC CRL1440) expressing recombinant human or cynomolgus CYP11B1 and CYP11B2 enzymes as described for an earlier compound in the series.20 Further details are provided in the online-only Data Supplement.
Copyright and License information: ©2016 The Authors.
Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.
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