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NSAIDs (indomethacin) induced gastric ulcer
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Animals were given a single dosage of indomethacin (20 mg/kg BW) orally 1 h after the last administration of the test substance. Nonsteroidal anti-inflammatory drugs (NSAIDs) were administered to the rats for 6 h before they were euthanized by an anesthetic overdose and dissected, then the stomach was removed.[15] The stomach was opened along its larger curvature and cleaned with a solution of serum physiological solution (0.9% NaCl). The mucosa was then exposed to determine the volume of gastric content, gastric content pH, and UI.[16]
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