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The following data were collected for each study included: inclusion and exclusion criteria, design, primary endpoint and population in which it was analyzed, definition of clinical cure, time point used for the test of cure (TOC) visit, and the statistical hypothesis. Data extraction from the studies was confirmed by an independent reviewer. At the end, a global quality assessment of each RCT was performed using an 8-item scale allowing calculation of a global quality score adapted to the focus of this systematic review.
Copyright and License information: The Author(s). ©2017
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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