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The grading of the evidence was done initially by DA and then discussed between all the authors to reach a conclusion. We used the World Cancer Research Fund (WCRF) grading criteria (Supplementary Table 7, Online Resource 4) for grading the overall evidence regarding vegetarian diets and CVD, IHD and stroke, with possible gradings rated as convincing, probable, limited-suggestive, limited-no conclusion, or substantial effect on risk unlikely [36, 37].

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