SOMAlogic SOMAscan assay

Approximately 160 μl of plasma per sample was used for the Somalogic SOMAscan Assay which uses a novel protein-capture aptamer-based technology (15). The SOMAscan platform provides a uniquely high-throughput proteomic screening analysis which allows characterization of dynamic changes in proteomic expression using a multiplex approach order of magnitude greater than other commercially available technologies. For this study the SOMAscan HTS Assay 1.3K was used and processed through the Center for Human Immunology at the National Institutes of Health. The assay included the measurement of 1,310 protein analytes.