2.1. UK Biobank cohort

The data used for this study was obtained from the UK Biobank cohort that is a large‐scale population‐based prospective cohort recruiting over half a million participants living across the United Kingdom aged from 40 to 69 years between 2006 and 2010 (Sudlow et al., 2015). The health‐related information, baseline socioeconomic characteristics, and lifestyle of all individuals were collected via questionnaire, interview, and anthropometric measurements. Biological samples of subjects were collected and used for biochemical tests and genome‐wide genotyping. All subjects signed their informed consent prior to participation. The present study was approved by the UK Biobank and obtained health‐related information of 34,316–85,247 subjects including genotypic data and several phenotypes, such as depression, anxiety, and life environmental factors.