Partial volume estimate analysis

To assess whether differences in the physiological parameters vary with the proportion of GM present in the voxels, we ran a partial volume estimate (PVE) analysis. Binarised masks were created from the GM PVE in individual subject functional space for different GM PVE ranges (7 bins of equal width from 0.1–0.8). Within each mask for each parameter (CBF, OEF and CMRO₂), median values were calculated. D_C was calculated using median values of OEF and CMRO₂ in each GM PVE range.