Improve Research Reproducibility A Bio-protocol resource
- Home
- Protocols
-
Concise Method
2.2. Pre-formulation studies: Solubility of CBD, THCV and CBG
Request a Protocol
Ask a
question
Favorite
The solubility of APIs including CBD, CBG and THCV was determined in various solvents including dimethyl sulfoxide (DMSO), N-Methyl-2-pyrrolidone (NMP), and PEG 400. Briefly, 100 mg of each API was dissolved in 0.5 mL of DMSO, NMP, PEG400 and vortexed until it dissolved completely. All the solutions were then visually observed for any undissolved particles. Further, all the solubility samples were centrifuged, and the supernatant were collected. Samples were then analyzed using HPLC for the amount of drug solubilized in each solvent.
Copyright and License information: ©2022
Do you have any questions about this protocol?
Post your question to gather feedback from the community. We will also invite the authors of this article to respond.
Post a Question0 Q&A
