2.1. Active Ingredient Screening

TCMSP (http://tcmspw.com/tcmsp.php) database was used to collect the effective components and related targets of the 11 herbs in RGLD. The screening criteria were oral bioavailability (OB) > 30% and drug-likeness (DL) > 0.18 [23, 24], since both of them played important roles in evaluating the activity of drugs. Finally, 216 active ingredients in RGLD were obtained in total. The corresponding number of the obtained ingredients in BX, CH, CPC, GC, HS, HQ, JH, TJH, XKC, YHS, and YC is 13, 17, 5, 92, 4, 36, 3, 8, 11, 49, and 13, respectively. The detailed information of herbal ingredients was shown in Table S1.